植物の生物活性物質探索 : わらびの発がん物質

概要

論文の詳細を見る
Naturally occurring carcinogens of plant origin were briefly reviewed. The historical background of the studies on the bracken carcinogen and the cattle bracken poisoning and some attempts at the characterization of the active principle(s) were described. Finally, ptaquiloside, an unstable glycoside of an illudane-type norsesquiterpene, was characterized as the active principle. On the basis of the chemical and biological nature of ptaquiloside, a biological assay method using a modified Ames' test and a chemical assay using thin-layer chromatographydensitometry were devised. By using these methods, several processed or untreated samples of the fern collected in different places, and in different seasons, were assayed for their ptaquiloside contents to show under what conditions the decomposition of ptaquiloside took place, the epidemiological meanings and whether or not they were safe as food. Wide occurrence of ptaquiloside-like compounds in the ferns of the Pteridaceae family was also revealed by the same methods and four new analogous compounds were isolated and characterized. These analogs and illudins S and M, sesquiterpenes of illudane-type from Basidiomycetes, were shown to have mutagenecity in the modified Ames' test and in chromosome abberation in CHL cells as ptaquiloside and were considered to be the carcinogens of the same type as ptaquiloside.
日本生薬学会の論文
1991-09-20