DNA Knots : Theory and Experiments(Statistical Physics and Topology of Polymers with Ramifications to Structure and Function of DNA and Proteins)

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概要

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• Cellular DNA is a long, thread-like molecule with remarkably complex topology. Enzymes that manipulate the geometry and topology of cellular DNA perform many vital cellular processes (including segregation of daughter chromosomes, gene regulation, DNA repair, and generation of antibody diversity). Some enzymes pass DNA through itself via enzyme-bridged transient breaks in the DNA; other enzymes break the DNA apart and reconnect it to different ends. In the topological approach to enzymology, circular DNA is incubated with an enzyme, producing an enzyme signature in the form of DNA knots and links. By observing the changes in DNA geometry (supercoiling) and topology (knotting and linking) due to enzyme action, the enzyme binding and mechanism can often be characterized. This paper will discuss some personal research history, and the tangle model for the analysis of site-specific recombination experiments on circular DNA.

• 2011-12-16

著者

• Sumners De

  Department Of Mathematics Florida State University

関連論文

• DNA Knots : Theory and Experiments(Statistical Physics and Topology of Polymers with Ramifications to Structure and Function of DNA and Proteins)

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