ベーチェット病 : 治療と病因研究の進歩

概要

論文の詳細を見る
Behcet's disease is a multisystemic inflammatory disorder characterized by recurrent episodes of oral ulcers, uveitis, genital ulcers and skin lesions. The aim of this paper is to summarize the recent advances in the therapeutic strategies for an refractory uveitis due to Bechet's disease, and to review the studies on the etiology of this disorder. None of the systemic anti-inflammatory agents, including cyclosporine, was sufficient to suppress the ocular attacks. Introduction of the anti-TNF alpha biologics for the treatment of severe uveitis greatly improved the visual prognosis. Though the etiology of this disease is still unclear, oral streptococci is supposed to play important role. Oral streptococci may elicit effectors, including γ δT cells in the oral cavity, and these cells cross react with mycobacterial and human heat shock proteins to cause the Th1 type inflammation in the selected organ. More recent studies have focused on Th17 and T reg cell function and are providing new insights about Behcet's disease.
2011-09-30