Modulation of Quinone Reductase, Alcohol Dehydrogenase and Cytochrome P450 2E1 Activities in Rat Liver by Aloe arborescens var. natalensis (Kidachi aloe)

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概要

• 論文の詳細を見る

• We examined the modulating effects of freeze-dried whole-leaf Aloe arborescens var. natalensis (hereinafter called ALOE) on the hepatic activities of quinine reductase (QR), alcohol dehydrogenase (ADH), aldehyde dehydrogenase (ALDH) and cytochrome P450 (CYP) 2E1-mediated p-nitrophenol (PNP) hydroxylase in rats. Male F344 rats (4 weeks old) were fed a basal diet or experimental diets containing 5%ALOE for 5 weeks. Dietary administration of ALOE significantly enhanced the activities of QR and ADH compared with controls. In contrast, the PNP hydroxylase activity was significantly reduced in rats fed the ALOE diet. On the other hand, no significant changes were observed in the ALDH activity in the ALOE-treated rats. These results indicate that ALOE may have beneficial effects on ethanol metabolism and toxicity.

• 日本生薬学会の論文
• 2004-02-20

著者

• Koike T

  Fujita Memorial Institute Of Pharmacognosy Fujita Health University

• Beppu H

  Fujita Memorial Institute Of Pharmacognosy Fujita Health University

• Shimpo Kan

  Fujita Memorial Institute Of Pharmacognosy Fujita Health University

• CHIHARA Takeshi

  Fujita Memorial Institute of Pharmacognosy, Fujita Health University

• BEPPU Hidehiko

  Fujita Memorial Institute of Pharmacognosy, Fujita Health University

• KANEKO Takaaki

  Fujita Memorial Institute of Pharmacognosy, Fujita Health University

• KUZUYA Hiroshi

  Fujita Memorial Institute of Pharmacognosy, Fujita Health University

• Kuzuya Hiroshi

  Fujita Memorial Institute Of Pharmacognosy Fujita Health University

• Chihara Takeshi

  Fujita Memorial Institute Of Pharmacognosy Fujita Health University

• Ida Chikako

  Fujita Memorial Institute Of Pharmacognosy Fujita Health University

• Kaneko Takaaki

  Fujita Memorial Institute Of Pharmacognosy Fujita Health University

関連論文

• Modulation of Quinone Reductase, Alcohol Dehydrogenase and Cytochrome P450 2E1 Activities in Rat Liver by Aloe arborescens var. natalensis (Kidachi aloe)
• A 35 kDa Mannose-Binding Lectin with Hemagglutinating and Mitogenic Activities from "Kidachi Aloe"(Aloe arborescens Miller var. natalensis Berger)
• Inhibition of cytochrome P450 2E1 activity by freeze-dried whole-leaf Aloe arborescens(Kidachi aloe)
• Modulation of Quinone Reductase, Alcohol Dehydrogenase and Cytochrome P450 2E1 Activities in Rat Liver by Aloe arborescens var. natalensis (Kidachi aloe)
• Effect of Different Types of Cyclodextrins on Gastrointestinal Absorption of α-Lipoic Acid in Rats and Humans

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