A Tyrosinase Inhibitor from the Wood of Asam (Mangifera quadrifida J.)

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概要

• 論文の詳細を見る

• Tyrosinase inhibiting compound from Asam wood (Mangifera quadrifida), which belongs to Anacardiaceae, was investigated to find whitening agents which could be used in cosmetic products. The natural compound which remarkably inhibited tyrosinase was found in ethanol eluate fraction separated by LH-20 gel chromatography from 50% aqueous ethanol extracts. This novel compound was identified as (4,6-Dihydroxy)-dihydrobenzofuran-3-yl-(3,4-dihydroxy)-phenyl ketone. It inhibited the oxidation of L-tyrosine (IC_<50> : 3.5μg/ml) more sturdily than that of L-3,4-dihydroxyphenylalanine (L-DOPA) (IC_<50> :16.7μg/ml), and suppressed the melanin biosynthesis in the B16 mouse melanoma cell line.

• 日本生薬学会の論文
• 2002-06-20

著者

• Takagi Keiji

  Faculty Of Bioresources Mie University

• Mitsunaga T

  Mie Univ. Tsu Jpn

• Mitsunaga Tohru

  Faculty Of Bilresources Mie University

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• A Tyrosinase Inhibitor from the Wood of Asam (Mangifera quadrifida J.)

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