The association between the thrifty genotype and energy expenditure during aerobic exercise in healthy males and females

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概要

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• The number of patients with diabetes is notably increasing in Japan. The thrifty genotype characteristics provide an explanation for this very high prevalence of diabetes. Especially, the Trp64Arg polymorphism in the β3-adrenergic receptor (β3-AR) gene is relatively common in Japanese people. Aerobic exercise is one of the major strategies for prevention and treatment of type 2 diabetes. The present study investigated whether the Trp64Arg polymorphism in the β3-AR gene is associated with a reduction in energy expenditure in aerobic exercise. Eighty-six non-obese healthy young people were recruited. Energy expenditure was measured using indirect calorimetry. The subjects performed an aerobic exercise program at 60% of their maximal heart rate for 30 minutes. The level of fat oxidation during aerobic exercise by male subjects with the Trp/Arg of the β3-AR gene was significantly lower than that by those with the Trp/Trp genotype. There was no difference observed in female subjects. It was demonstrated that the Trp64Arg polymorphism in the β3-AR gene is associated with the reduction of fat oxidation during aerobic exercise in healthy young males.

• 藍野大学の論文

著者

• Morita Emiko

  Department Of Physical Therapy Faculty Of Nursing And Rehabilitation Aino University

関連論文

• The association between the thrifty genotype and energy expenditure during aerobic exercise in healthy males and females

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