肥満と炎症 : メタボリック症候群の概念の変遷と病態の理解

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There are two types of obesity. They are hypodermic fat type obesity whose fat attaches to the lower half of the body and visceral fat type obesity. Especially, obesity caused by the fat accumulation in internal organs leads to the metabolic syndrome. The metabolic syndrome is a condition that closely relates to the cardiovascular disease caused by the progress of arteriosclerosis among life style disease, which is based on insulin resistance, abnormal lipoproteinemia and high blood pressure. Recently, the mechanism and the role of fat cells in the progress of arteriosclerosis have been clarified, which indicates that fat cells secrete the inflammatory cytokines. The overweight child increases in this country, which accounts for 15% of the entire child. Moreover, 80% of the infant's obesity continued growing fat after becoming adults and causes the metabolic syndrome. Therefore, a high concern came to be paid about the guidance about the custom of meal and exercise to prevent the infant's obesity though the ratio where abnormality admitted by the check up was less than 3% of the whole. In "Health Japan 21"that aimed at the national health movement during the 21st century, nine problems for the improvement of the lifestyle that could be causes of life style disease have been selected, where the direction of the approach that included a concrete numerical value was decided. The item related to the lifestyle disease located in the first is nourishment and eating habits, and the body activity and the exercise located next are aiming at the prevention of obesity among those problems. Although fiscal year 2010 is made target of This "Health Japan 21", the target has not been attained because adult's obesity rate has not been decreased in our country.

肥満と炎症 : メタボリック症候群の概念の変遷と病態の理解

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