712 組織再生促進のためのシグナル担持生体材料(OS5-(2) インプラントおよび生体材料,オーガナイズドセッション)

概要

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Biomaterials loaded with signals that stimulate or induce tissue regeneration in situ are practically useful. Fibroblast growth factor-2 (FGF-2) is one of such signals. FGF-2-apatite composite layers were formed on anodically oxidized titanium external fixation pins using a supersaturated calcium phosphate solution supplemented with FGF-2.The composite layer consisted of polycrystalline poorly crystallized apatite loaded with FGF-2. The pins were percutaneously implanted in both proximal tibial metaphyses in rabbits for 4 weeks. The pins with the FGF-2-apatite composite layer showed a significantly lower pin tract infection rate (44%) than those with apatite layer (94%). Extensive angiogenesis and bone formation was observed around the pins with the composite layer. In some cases, Sharpey's-fiber-like collagen fibers were regenerated around the pins with the composite layer.
2009-08-25