303 MRIを用いた軟骨機能評価の試み(OS3-(1) バイオメカニクスにおける新分野の開拓 : 組織粘弾性の無侵襲計測,オーガナイズドセッション)

概要

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The function of the articular cartilage depends on transfer of the water from the tissue. The course of changes of the Apparent Diffusion Coefficient (ADC) and Magnetization Transfer Contrast (MTC) effect (Ms/Mo) of articular cartilage during mechanical compression were observed for evaluation of the cartilage function as extra vivo and in vivo study. On the extra vivo study, the ADC and Ms/Mo of the bovine cartilage decreased under compression, and increased by removal of compression. These results suggest that water content in the cartilage decreased, internal pressure increased, and a gap of the extracellular matrix decreased due to transformation of the collagen meshwork. Furthermore, the Ms/Mo in patellar cartilage slightly changed between with and without weight bearing in healthy subjects. This result suggests that water content or hydrate states within patellar cartilage changed by weight bearing. This extra vivo study also provides sample experimental support for our recent in vivo study.
2009-08-25