Techniques and applications of multi-modality small animal imaging in cancer research (医用画像)
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概要
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Small-animal models are extensively used in disease research, genomics studies, drug development, and developmental biology. The development of noninvasive small-animal imaging techniques with adequate spatial resolution and sensitivity is of prime importance. In particular, multimodality small-animal imaging can provide complementary information that single modality cannot offer. This paper presents the role of high frequency ultrasound(microUS)in multimodality small animal imaging for cancer research and progress for microUS and small-animal positron-emission tomography(microPET)multimodality small animal imaging. The following demonstrations are included. First, registration of microUS/microPET is performed using a three-dimensional registration method. In addition, microUS was combined with microPET for tumor progressive assessment. MicroUS provides anatomical information which can be used for tumor volume measurements while microPET is a functional imaging method with positron-emitting radiopharmaceuticals, such as 18F-labeled deoxyglucose, [18F]FDG. To investigate the feasibility of the functional information provided from microUS, contrast enhanced ultrasound(CEUS)technique is an alternative way to characterize three vascular contrast phases of liver focal lesions in small animal. Finally, the multimodality N-succinimidyl-4-[18F]fluorobenzoate labeled tumor angiogenesis-related vascular endothelial growth factor receptor 2 targeted microbubbles(tMBs)were synthesized and the biologic characteristics of the tMBs in human breast-cancer-bearing mice were investigated with microPET and microUS.
- 一般社団法人電子情報通信学会の論文
- 2010-01-21
著者
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Li Pai-chi
Faculty Electrical Engineering National Taiwan University
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Liao Ai-ho
National Taiwan University