＜Poster＞Effect of a free radical scavenger, edaravone, on free radical reactions : Related signal transduction and cerebral vasospasm in the rabbit subarachnoid hemorrhage model

概要

論文の詳細を見る
OBJECTIVE: It is hypothesized that free radical reactions evoked by oxyhemoglobin （oxyHb） causecerebral vasospasm after aneurysmal subarachnoid hemorrhage （SAH）, even though the detailed mechanismshave not yet been fully established. The aims of this study were thus to investigate, through the use of the doublehemorrhagerabbit model, the possibility that using a potent free radical scavenger, edaravone, will show ameliorationof cerebral vasospasm, and to delineate the mechanism of signal transduction that causes cerebral vasospasm.METHODS: In the SAH group, SAH was simulated using the double-hemorrhage rabbit model. In the treatmentgroup, edaravone （0.6 mg/kg） was injected into the central ear vein. Ninety-six hours after SAH, the basilar arterywas excised. The degree of cerebral vasospasm was evaluated by measuring the diameter of each basilar artery,and the expression of Rho-kinase in the vascular wall was examined by Western blotting. RESULTS: The diameterof the basilar artery in the edaravone-treated group was 0.71 ± 0.06 mm, which was statistically signifi cantly largerthan that in the nontreated SAH group （0.50 ± 0.03 mm; P < 0.01）. The expression of Rho-kinase in the edaravonetreatedgroup was statistically signifi cantly reduced in comparison to that of the nontreated SAH group （P < 0.01）.CONCLUSION: Results from this study indicate that edaravone may potentially serve as an agent in the preventionof cerebral vasospasm in patients after SAH. In addition, it might be suggested that the free radical reaction mediatedby oxyHb is concerned with the regulation of the Rho/Rho-kinase pathway.
弘前大学の論文

＜Poster＞Effect of a free radical scavenger, edaravone, on free radical reactions : Related signal transduction and cerebral vasospasm in the rabbit subarachnoid hemorrhage model

スポンサーリンク

概要

著者

関連論文

スポンサーリンク