＜Symposium I＞Genetic dissection of age-related memory impairment in Drosophila

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Age-related memory impairment （AMI） is an important phenotype of brain aging. Understandingthe molecular mechanisms underlying AMI is important not only from a scientific viewpoint but also for thedevelopment of therapeutics that may eventually lead to developing drugs to combat memory loss. AMI has beengenerally considered to be an overall or nonspecifi c decay of memory processes that results from dysfunction ofneural networks. However, extensive behavioral genetic characterization of AMI with Drosophila demonstrated thatAMI results from disruption in specifi c memory process. In Drosophila, memory acquired after a single olfactoryconditioning paradigm has three distinct phases: short-term memory （STM）, middle-term memory （MTM）, andlonger-lasting anesthesia-resistant memory （ARM）. Significantly, AMI results from the specific decay of onlyone memory component, amn-dependent MTM, and not other components. Since amnesiac encodes peptides thatregulate adenylyl cyclase activity, these studies suggest the importance of the cAMP signaling pathway in AMI inDrosophila, a fi nding consistent with several models of AMI in mammals. In fact, hypomorphic mutations in PKAcatalytic subunit signifi cantly suppress AMI. As cAMP signaling is an essential signaling for learning and memory,these studies suggest antagonistic pleiotropic eff ect of cAMP signaling. Due to its short lifespan, powerful genetics,and well-characterized and conserved pathways involved in memory and lifespan, Drosophila will be a useful modelsystem for studying the molecular mechanisms underlying this process.

＜Symposium I＞Genetic dissection of age-related memory impairment in Drosophila

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