＜Symposium I＞Prandial increases of leptin and orexin in the brain modulate spatial learning and memory

概要

論文の詳細を見る
Leptin is well known to be involved in the inhibition of feeding, thermogenesis, reproduction andneuroendocrine functions through its actions on the rodent hypothalamic receptors. Leptin facilitated the presynaptictransmitter release and postsynaptic sensitivity to the transmitters in the hippocampal CA1 neurons. Thus longtermpotentiation （LTP） and the phosphorylation of Ca2+/calmodulin protein kinase II （CaMK II） were facilitatedin the CA1 neurons. Therefore behavioral performance related to spatial learning and memory was improved byleptin in vivo applications. Orexin-A produced by glucose-sensitive neurons in the lateral hypothalamic area （LHA）and released during food intake facilitates feeding. Orexin-A suppressed LTP and CaMK II phosphorylation withoutaffecting the presynaptic transmitter release. Therefore behavioral performance on learning and memory wasimpaired. The present studies suggest that leptin and orexin signalings in the brain may have important implicationsfor cognitive function.