A-23 分子鎖長の異なるPEGを介してRGDペプチドを固定化したチタンの軟組織適合性の差異(チタン・歯科用合金,一般講演(口頭発表))

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The creation of biomaterial surfaces which has good cell adhesiveness is important to develop new biomaterials. In this study, cell adhesive peptide, RGD, was immobilized on titanium through zwitterionic poly (ethylene glycol), NH_2-PEG-COOH, with different length of molecular chain. The differences of immobilized manners among various length of molecular chains and cell adhesiveness were investigated. As a result, the density of NH_2-PEG-COOH immobilized on titanium was decreased when the NH_2-PEG-COOH was long. Moreover, the amount of RGD peptide which intervened between NH_2-PEG-COOH chains or directly immobilized on titanium was large when NH_2-PEG-COOH was long. Furthermore, the difference of NH_2-PEG-COOH length affected to cellular adhesiveness.
2010-03-25