糖尿病患者の呼気中アセトン濃度,口中気体中の揮発性硫黄化合物濃度および歯周病有病状態に関する研究
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Although diabetes patients show relatively higher acetone concentrations in the expired air and a higher prevalence of periodontitis, the precise relationships to diabetic conditions remained to be elucidated. In this study, concentrations of acetone and volatile sulfur compounds (VSC) in the expired airs from 35 patients with Type 2 diabetes mellitus were investigated in relation to their periodontal status. The diabetic condition was assessed by the concentration of glycohemoglobin A_<1c> (HbA_<1c>) in the blood. The concentrations of acetone and VSC in the expired airs were measured gas-chromatographically, and the periodontal status was assessed by CPI criteria. The results of the single correlation analyses revealed that the concentration of acetone in the expired air showed a positive correlation with HbA_<1c>, but not with the periodontal condition nor the VSC concentration. In comparison between the diabetes patients group and the control subjects, the concentration of acetone and the prevalence of subjects with the periodontal pocket of over 4mm (CPI>=3) were significantly higher in the diabetes group than those in the control group. However, there was no significant difference in VSC concentration as well as the amount of tongue coat between the groups. Further assessment on the periodontal bacteria in the tongue coat samples indicated that the proportion of Porphyromonas gingivalis showed a positive correlation with periodontal status both in the diabetic and healthy subjects. Consequently, it was strongly suggested that measuring the concentration of acetone in expired air, which was independent from the periodontal conditions, could be a useful tool to find the high risk individuals with diabetes mellitus. On the other hand, VSC concentration in expired air could not be related to diabetic and periodontal status in diabetic patients. It was also demonstrated that the prevalence of periodontitis in the diabetes group was significantly higher than that in the healthy subjects, and that the periodontal status was positively related to the diabetic conditions. In addition, the proportion of P. gingivalis in the tongue coat could be associated to their periodontal status both in the diabetic and healthy subjects.
- 2010-04-23
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関連論文
- 糖尿病患者の呼気中アセトン濃度,口中気体中の揮発性硫黄化合物濃度および歯周病有病状態に関する研究
- 糖尿病患者の呼気中アセトン濃度, 口中気体中の揮発性硫黄化合物濃度および歯周病有病状態に関する研究
- 糖尿病患者の呼気中アセトン濃度,口中気体の揮発性硫黄化合物濃度および歯周病有病状態に関する研究(岩手医科大学学位審査報告)
- 演題1.糖尿病教育入院患者56名の口腔内状況と問題点(一般演題,岩手医科大学歯学会第65回例会抄録)