プロポフォールによる静脈内鎮静法時の健忘効果からの回復 : 視覚性記憶課題負荷による検討

概要

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This study was planned to investigate whether bispectral index (BIS) value, calculation intracerebral concentration and the elapsed time from propofol (PPF) stop serve as an index of the recovery from amnesia. The amnesia effect was evaluated by the rate of the memory of visibility memory load which was shown a set of five-sheet pictures. A set of pictures were loaded in the maintenance and recovery term. After the full recovery from sedation, the pictures memorized by the object were counted. In Control group, research was done on the same schedule as PPF group but by saline instead of PPF. A correlation between the BIS value and OAA/S scale was observed. BIS recovered to control value was 10 minutes after stopping PPF. The rate of the memory kept about the control value 10 minutes after stopping PPF, there was no significant difference between control values. Calculation intracerebral concentration fell to about 0.7μg/ml by the stop, and had a correlation with the rates of the memory. In conclusion, these results suggest that the recovery from amnesia by PPF is obtained on the following conditions. 1) Over 10 minutes after PPF administration stop 2) BIS value over 86 3) Calculation intracerebral concentration under 1.1μg/ml
2010-04-23