排尿時の血行動態変化における交感神経活動の役割
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概要
- 論文の詳細を見る
Micturition with considerable bladder deflation induces a high incidence of circulatory disorders, such as syncope, cerebro-vascular accident and cardiac attack. To examine this mechanism, observations were made on influence of the vesical pressure change on hemodynamics and sympathetic activity in 25 human subjects and 31 rats. In 15 men, vesical pressure load of 23cmH_20 with warmed boric acid solution caused increases in mean blood pressure by 15% and cardiac rate by 22%. Blood levels of catecholamine and Dopamine-β-Hydroxylase activity were increased by 60% and 25%, respectively. In patients with essential hypertension, a rise of blood pressure was more prominent as compaired to patients with angina pectoris and those with arrhythmia. In male rats, the 60cmH_20-pressure load induced a marked rise of BP by 32%, heart rate by 10% and blood flow of common carotid artery by 23%. A marked enhancement of sympathetic activity taken from cervical sympathetic trunk, inferior cardiac, splenic and hypogastric nerves, was observed. Elevated blood pressure, increased cardiac rate and blood flow of common carotid artery changed markedly after rapid deflation of loaded bladder and attained to the lower level than control. Simultaneously, sympathetic activity was diminished significantly. From those results, it was concluded that pronounced fluctuation of vesical pressure induced remarkable hemodynamic change through the alternation of sympathetic activity.
- 神戸大学の論文