胆汁分泌の機構に関する実験的研究 : 種々抗生物質の胆汁分泌に及ぼす影響について
スポンサーリンク
概要
- 論文の詳細を見る
The effects of antibiotics on bile secretion were investigated using Wistar strain male rats. As antibiotics, Cefalothin (CET), Cefazolin (CEZ), Sulbenicillin (SB-PC), Calbenicillin (CB-PC), Thiamphenicol (TP), and Tetracycline (TC) were intravenously administered in divided doses, each dose being 1g/kg of body weight for CET, CEZ, SB-PC, CB-PC and TP and 125mg/kg for TC. Five 30-minutes fractions of bile were collected following each antibiotic injection, and the same collection was followed after the second injection. The same volume of saline as drained bile was repeatedly given i. p. Bile flow immediately increased after the administration of CET, CEZ, SB-PC and CB-PC, the volume of the first fractions being the maximum and about twice as much as that in control. The volume of the fifth fractions returned to alrr.ost the same as that in control. The second administration of these four drugs were again followed by the same responses of bile flow. On the contrary, TC was followed by a decreased flow, and TP induced little change as in saline control. Secretion of bile acids into bile was significantly decreased by CET, CEZ and SB-PC, though no significant decrease was observed after CB-PC, TP and TC. As for biliary secretion of cholesterol and phospholipids, all of these antibiotics except CET had decreasing effect. CET also decreased biliary secretion of phospholipid, however, the decreasing effect on cholesterol secretion was minimum. The correlation between biliary bile acid and cholesterol suggested that bile acid independent secretion of biliary cholesterol was decreased by antibiotics. Bile acid dependent secretion of phospholipids was also considered to be reduced after antibiotic administration. The composition of biliary bile acids which was determined by gas-liquid chromatography did not show any significant change after CET administration. These findings suggest that we should be very careful in giving antibiotics, especially after biliary operations, considering the effects of antibiotics on liver cells.
- 神戸大学の論文