脂肪乳剤の代謝と老人高カロリー輸液への応用について
スポンサーリンク
概要
- 論文の詳細を見る
Present study was undertaken to reveal the metabolism of the intravenously administered fat emulsion and its metabolic changes in the aged, using 1-<14>^C-fatty acid labelled soy bean oil emulsion. The application of fat emulsion to total parenteral nutrition (TPN) in the aged was also discussed experimentally and clinically. Cumulative expired <14>^CO_2, tissue distribution of radioactivity and chronological changes of lipids and their fatty acids composition revealed that the intravenously administered fat emulsion was rapidly eliminated from the circulation and metabolized well to CO_2 at half of administered dose for 6 hours and that the remnant of the administered fat emulsion was converted to the endogenous lipids almost completely for several hours. The oxidation of fat emulsion in the aged was about 80% of that in the youth at 1g/kg admlilistration, inistration, while it was depressed more in proportion to increase in administered dose. The long retained higher % radioactivity in liver and spleen with increased TG in liver also supported the decreased lipids metabolism in the aged. However, long term continuous usage of fat emulsion in TPN induced the increase in fat utilization of the aged to the level of the youth. In fat loading to patients the plasma postheparin LPL activity in the aged was lower in its peak than that in the youth, while plasma lipids showed no significant differences between aged and youth. Throughout the course of TPN with fat emulsion in aged patients, no significant changes in plasma lipids and liver function showed that the administered fat emulsion in TPN was well metabolized and tolerated until the dosage of 1g/kg/day in the aged.
- 神戸大学の論文