血液ガス運搬体としてのperfluorochemicals乳剤投与時の実験病理学的研究
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概要
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The histological identification of Perfluorochemical (PFC) emulsion and its pathological studies were performed in the organs of animals after intravenous administration of various PFC emulsion. FDA emulsion that was new and most prospective in clinical application was studied pathologically in rhesus monkeys. Following results were obtained : 1. Vesicles seen in reticuloendothelial cells and hepatic cells after the administration of PFC emulsion were just PFC particles themselves with equipped with unit membrane, showing phagolysosomal type sometimes. 2. The PFC particles with unit membrane were possibly excreted again to the extracellular spaces by reverse pinocytosis. 3. PFC-emulsion was phagocytized in the reticuloendothelial cells of the liver and the spleen and so forth, in which foamy cells with numerous PFC particles were contained. No foreign body reaction could be found in all organs. Furthermore, electron microscopical findings revealed the intact structure of intracellular organellae. 4. The morphological changes after administration of FC 43 emulsion were severe and lasting, while those of FDA emulsion were mild and transient. Thus. morphological changes after administration of PFC emulsion were revealed to be proportional to the amount of the accumulation in the organs. 5. The pathological changes administered FDA emulsion in monkeys were almost similar to those in rats. At the monkeys performed nearly total exchange transfusion, distal tubules of the kidney showed mild swelling and vacuolar formation. that were thought to be transient and reversible because of hypoxic effects. On the other hand, no pathological changes could be found in no hypoxic state monkeys by FDA administration. Therefore, though FC-43 emulsion and so on were thought to be inappropriate for the usage as artificial blood, FDA emulsion was revealed to be probably applied clinically as blood gas carrier in emergency case.
- 神戸大学の論文