肝切除ラットの胆汁酸代謝に関する実験的研究
スポンサーリンク
概要
- 論文の詳細を見る
The bile acid metabolism after 60-70% hepatectomy was investigated using Wistar strain male rats weighing 250-300g. Hourly secretion of bile acids into bile remarkably decreased after the operation, though biliary secretion of cholesterol and phospholipids per one hour did not change. Bile flow per one g. of liver did not show any significant change before and after the operation. In regard with the percentile composition of biliary bile acids, CDCA and its derivatives (CDCA group) decreased on one hand, CA and its derivatives (CA group) increased after the operation on the other hand. Quantity of bile acids in the small intertine, the large intestine, bile, liver and plasma was measured respectively, defining the sum as pool size of bile acid. Bile acids in the small intestine occupied almost constantly around 85% of the pool size. The pool size decreased following the operation, showing the lowest value at the 4th day and exceeded the preoperative value at the 14th day. Postoperative changes of the pool size were in parallel with changes in small-intestinal bile acids. As for each bile acid in the pool size, CDCA group decreased after the operation, though CA group showed little change. After partial hepatectomy urinary bile acids remarkably increased, though fecal bile acids decreased. The quantity of bile acids in feces far exceeded urinary bile acids, therefore, daily excretion of bile acids decreased after the operation. Since the daily excretion of bile acids can be considered as daily synthesis in usual situation, the fact that the total amout of excreted bile acids for the first 14 days after the operation decreased, may signify that the synthesis of bile acid decreased during the period. From foregoing findings, the assessments of bile acid metabolism before and after hepatic resection seem to be considered very helpful and crucial in taking care of hepatectomized patients.
- 神戸大学の論文