腎性の二次性上皮小体機能亢進症における上皮小体の研究 : 1,25-dihydroxyvitamin D_3 receptor密度と細胞増殖能との関係

概要

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To clarify the relationship between the 1,25-dihydroxyvitamin D_3 receptor (VDR) density and proliferative activities of parathyroid cells, 18 parathyroid glands surgically removed from patients suffering from secondary hyperparathyroidism due to chronic renal failure were examined histologically and immunohistochemically with anti-VDR antibody and antiproliferating cell nuclear antigen (PCNA) antibody. This revealed a significantly lower positive VDR staining ratio in nodular hyperplasia (nodular type) of the parathyroids than in diffuse hyperplasia (diffuse type). The number of positive PCNA staining cells in nodular type was significantly greater than in diffuse type. A negative correlation was found between VDR density and PCNA expression. These results indicated that the decrease in VDR density was associated with the proliferative activity of the parathyroid cells in secondary hyperparathyroidism.
東京女子医科大学の論文
1996-12-25