インスリン非依存型糖尿病(NIDDM)における微量アルブミン尿と血管障害との関連
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概要
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The aim of the present study was to elucidate whether non-insulin-dependent diabetics with microalbuminuria have associated with atherosclerotic vascular damage by using plasma endothelin, fibrinogen and von Willebrand factor (vWF) as markers. Seventy-six non-insulin-dependent diabetic patients (48 men and 28 women: mean age, 51 ± 10 yrs) without overt proteinuria or cardiovascular disease were studied. Patients were assigned two groups based on their timed overnight urinary albumin excretion rate (AER): a normoalbuminuric group (AER < 10 μg/min) consisting of 47 patients (25 men and 22 women: mean age 46 ± 14 yrs) and a microalbuminuric group (AER: 10～200 μg/min) consisting of 29 patients (23 men and 6 women: mean age 54 ± 7 yrs). The plasma endothelin concentrations in the microalbuminuric group (3.2 ± 0.5 pg/ml) were significantly higher than in the normoalbuminuric group (2.0 ± 0.4 pg/ml, p<0.05) Plasma fibrinogen concentrations in the microalbuminuric group (353.4 ± 15. 6 mg/dl) were also significantly higher than in the normoalbuminuric group (291.3 ± 11.8 mg/dl, p<0.05), but there was no significant difference between the plasma VWF concentrations in the two groups. These findings suggest that microalbuminuria can serve as an important and useful marker for the presence of vascular endothelial injury, as well as diabetic nephropathy, in patients with diabetes mellitus.
- 東京女子医科大学の論文
- 1996-07-25
著者
関連論文
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- 糖尿病性腎不全に対する腎移植の予後に関する研究
- (49)インスリン非依存型糖尿病(NIDDM)における微量アルブミン尿と血管障害の関連(学位論文内容の要旨および審査の結果の要旨第36集)
- インスリン非依存型糖尿病(NIDDM)における微量アルブミン尿と血管障害との関連
- 1.急激な血糖上昇で発見し,膵部分切除後経口血糖降下剤で良好な経過を示した膵癌・膵性糖尿病の1例(研修医症例報告,第335回東京女子医科大学学会例会)