HLA-B27抗原関連急性前部ぶどう膜炎の臨床像についての検討

概要

論文の詳細を見る
An objective investigation of the clinical features of HLA-B27-associated acute anterior uveitis (HLA-B27 AAU) was performed using a laser flare cell meter, and by laboratory testing of peripheral blood. The study involved 42 patients (31 men and 11 women, mean age at onset 31.3 years) with HLA-B27 AAU, 33 patients with HLA-B27 negative AAU, and 40 patients with Behcet's disease. The flare intensity was significantly higher at their first attack in HLA-B27(+) patients than in HLA-B27(-) patients. There was a significantly higher incidence of worsening of the flare intensity in HLA-B27(+) patients (12 out of 58 attacks, 21.4%) than in HLA-B27(-) patients (4.8%) and those with Behcet's disease (0%). Anti-chlamydia IgA antibody titers (1.57 ± 0.65) (ELISA) were significantly higher in HLA-B27(+) patients than in patients with Behcet's disease (1.01 ± 0.26) and normal controls (1.01 ± 0.29). In HLA-B27(+) patients, the peripheral blood leucocyte counts, C-reactive protein levels, serum IgM titers, complement titer (CHSO) were higher than in normal controls or HLA-B27(-) patients or those with Behcet's disease. These results suggest that the activity and intensity of inflammation in HLA-B27 AAU are more severe than with HLA-B27(-) AAU and Behcet's disease.
東京女子医科大学の論文
1997-12-25