人工閉経における血清Interleukin-6およびSoluble Interleukin-6 Receptorの動態と骨代謝との関係

概要

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Interleukin-6 (IL-6) has been postulated to play a role in the pathogenesis of postmenopausal osteoporosis. The study included 46 premenopausal women; 30 healthy women underwent abdominal surgery without bilateral oophorectomy and 16 healthy women underwent total hysterectomy with bilateral oophorectomy. To test this hypothesis, we measured circulating levels of IL-6, soluble interleukin-6 receptors (IL-6sR) and other bone biochemical markers; tartrate-resistant acid phosphatase (TRACP), intact osteocalcin (I-OC), bone alkaline phosphatase (B-ALP) and urinary deoxypyridinoline (D-Pyr) corrected for urinary concentration according to individual creatinine values. Laboratory parameters were tested before surgery and 1 month, 3 months and 6 months after surgery in all patients. Additionally bone mineral density (BMD; L2-L4) was tested before surgery and at 6 months. A significant increase in the levels of serum IL-6sR, TRACP at 3 months and in serum B-ALP and I-OC and urine D-Pyr at 6 months were reported. BMD decreased by 5.6% at 6 months. IL-6sR correlated with TRACP at 3 months after surgery. No significant variation was observed in the women without bilateral oophorectomy at any period of the study. These results confirm that IL-6sR play an important role in regulating bone resorption in postmenopausal osteoporosis.
東京女子医科大学の論文
1997-11-25