膵島移植部位としての小腸漿膜下の有用性

概要

論文の詳細を見る
In this study we compared the small bowel subserosal space (SBSS) and a liver omental pouch (LOP) to the classical portal vein (PV) site for islet implantation. Lewis rat islets were isografted into three different transplantation sites in streptozotocin-induced diabetic recipient rats. The SBSS was created by configuring part of the deserosalized jejunum into a U shape whilst the inferior surface of the liver and greater omentum were used to form the LOP. At postoperative day 30, normoglycemia was achieved in 100% (12/12), 80% (8/10), and 50% (5/10) of the PV, SBSS and LOP groups respectively. In successful transplants, the majority of recipients exhibited sustained graft function. Oral glucose tolerance tests revealed that glucose tolerance was comparable in rats with either SBSS or PV islets. Morphologically, many intact islets were evident in the SBSS of normoglycemic recipients, whereas only islets adjacent to the liver surface survived in the LOP group. SBSS is easily accessible for surgical implantation and biopsy and well placed for portal delivery of insulin. In addition, it is capable of local drug delivery. Our results demonstrate that the SBSS is an alternative site for islet transplantation.
東京女子医科大学の論文
2001-10-25