Duchenne型筋ジストロフィーにおける人工呼吸管理(東京女子医科大学東医療センター小児科開局40周年記念論文集)

概要

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Respiratory management, including the effects of mechanical ventilation on survival, was evaluated in 54 patients with Duchenne muscular dystrophy. Patients were provided with noninvasive positive pressure ventilation and observed from August 1994 to November 2006. Hypoventilation was evaluated by spirometry and nocturnal oxymetory monitoring. A vital capacity of less than 1L or less than 20% of that predicted, as well as periodic desaturation dips, were important. Because patient requirements change over time, serial evaluations were done, and the positive pressure ventilation adjusted if necessary. Careful serial assessment of nocturnal oxymetory monitoring was also useful for detecting changes in patient condition. Introducing artificial respiratory as part of the routine respiratory management in patients with Duchenne muscular dystrophy resulted in 5- and 10-year survival rates of 78 and 57%, respectively.
東京女子医科大学の論文
2007-05-31