低酸素室を用いた低酸素トレーニングと虚血プレコンディショニングを介した脳梗塞予防に関する仮説(神経内科学教室岩田誠教授退任記念特別号)

概要

論文の詳細を見る
Sublethal tissue ischemia (hypoxic stress) provides tolerance to subsequent ischemic insults. This phenomenon is known as ischemic preconditioning. At high-altitude, a dynamic autoregulation mechanism occurs to maintain homeostasis in the body. In terms of ischemic preconditioning, various physiological, cellular and molecular adaptations occur at high altitude to maintain homeostasis, including the alteration of the vascular system (vasodilation) and the induction of anti-apoptosis gene expression. In this review article, I will perform a literature review on ischemic preconditioning in the field of clinical neurology, and discuss the putative role of ischemic preconditioning approach to prevent cerebrovascular disease. In addition to Cerebrovascular disease, "Hypoxic training performed in a hypoxic chamber" may be extended to prevention of other hypoxia-related conditions such as ischemic heart diseases.
東京女子医科大学の論文
2008-02-25