(1)ホルモン補充療法で美しく(<シンポジウム>Well-aging-rejuvenation医療の現状,第73回東京女子医科大学学会総会)

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Dermatological changes conventionally associated with peri- and postmenopausal women include "increased freckles", "dryness of the skin", and "a loss of elasticity and flexibility". However, very few of the women who visit menopausal clinics complain of these dermatological changes. Furthermore, skin manifestations proposed as part of the menopausal indices by Kupperman et al. are rarely used in Japan except "formication" as part of the indefinite complaints suggestive of the menopausal syndrome. However, recent reports from Europe and the USA on the usefulness of hormone replacement therapy (HRT) in alleviating these dermatological symptoms have helped to direct attention to these dermatological symptoms in Japan, as a compelling issue that needs to be addressed to improve the quality of life (QOL) of women during and after menopause. In this article, we have described the physiological changes in the skin that occur with aging and decreasing estrogen in women and have explored the benefits of HRT in improving these dermatological symptoms (i.e.,reju-venation of the skin), in addition to our experience with HRT in outpatients. The three most common complaints among our patients are "I have prominent freckles", "the skin feels extremely dry", as well as "I have an itching sensation", and these dermatological symptoms are found to be as frequent as other menopausal symptoms. Furthermore, "increased water content in the stratum corneum", "decreased perspiration", and "decreased skin temperature" have been found to characterize the typical physiological changes that occur in the skin after menopause. Reports also indicate that HRT helps to maintain skin elasticity, skin thickness and sebum content in women of menopausal age which suggest the need for further research on the role of HRT in dermatological as well as in gynecological practice as an area worthy of further exploration and research.
東京女子医科大学の論文

(1)ホルモン補充療法で美しく(<シンポジウム>Well-aging-rejuvenation医療の現状,第73回東京女子医科大学学会総会)

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