STUDIES ON THE ANTIGENICITY OF THE HUMAN TROPHOBLAST CELL BY MICROCYTOTOXICITY TEST

概要

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The microcytotoxicity test has been employed to study the antigenic nature of the trophoblast cell at early gestational age, its specific nature and the effect of addition maternal serum into the culture on cytotoxicity caused by lymphocytes. Lymphocytes from 28 non pregnant women (control lymphocytes) showed significant cytotoxicity to the allogenic trophoblastic cells. Lymphocytes from 33 pregnant women showed significant cytotoxicity to autochthonous trophoblastic cells. In several cases (28.5%), a specific reduction in cultured trophoblasts by maternal lymphocytes was observed when they were compared with the control lymphocytes. In a few cases (16.6%) a specific reduction in cultured trophoblasts by allogeneic pregnant lymphocytes was observed when they were compared with the control lymphocytes. These effects of cytotoxicity were blocked by the addition of maternal sera in three out of four cases. In conclusion, it was suggested that the human trophoblast during early pregnancy does possess histocompatibility antigen and tissue specific antigen, that some maternal lymphocytes were sensitized to trophoblast cells and that the presence maternal serum in the culture inhibits the lysis of trophoblast.
名古屋市立大学の論文
1977-08-28