THE EFFECT OF INCREASED OXYGEN TENSION BY HYPERBARIC OXYGENATION ON AMINO ACID METABOLISM
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概要
- 論文の詳細を見る
An attempt was made to estimate the effect of increased oxygen tension for 60 min by oxygenation under high pressure of 2 Atomosphere Absolute with 100% O_2 on the metabolic balance in vivo through amino acid pool. In postabsorptive rabbits, total amino acids level was not changed significantly. However, ratio of glucogenic amino acids, especially alanine, was decreased, meanwhile each ratios of ketogenic amino acids, especially leucine,and branched chain amino acids was increased in Lactated Ringer's, 5% Glucose and 10% maltose administered groups. Also ratio of the amino acids passing through pyruvate to TCA cycle was decreased, on the other hand, ratios of the through acetyl CoA and the through α-ketoglutarate were increased remaining the through oxaloacetate unchanged in above groups. In 5% Fructose administered group, changes of amino acids were not significant. In 5% Xylitol administered group, decreased branched chain amino acids, increased ratio of the through exaloacetate and unchanged ratio of leucine were different from other groups. Increaseing tendencies of histidine and phenylalanine were noted in all groups. Blood glucose level was decreased in Lactated Ringer's administered group, but plasma insulin level was unchanged. From above data, it is suggested that metabolic acceleration of anaerobic glycolysis accompanied by protein catabolism and impeded TCA cycle along with disturbed lipid metabolism in rabbits. However, in male adults, the metabolic effect of increased oxygen tension for 60 min by oxygenation under high pressure of 2 Atomosphere Absolute with 100% O_2 were little than in rabbits.
- 名古屋市立大学の論文
- 1979-11-30
著者
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湯佐 子
Department Of Anesthesiology College Of Health Science University Of Ryukyus
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湯佐 [トシ]子
Department of Anesthesiology, College of Health Science, University of Ryukyus