ACID PHOSPHATASE AND β-GLUCURONIDASE ACTIVITIES OF T, B, Tγ AND Tμ LYMPHOCYTES IN PATIENTS WITH SARCOIDOSIS
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概要
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Acid phosphatase and β-glusuronidase activities of T, B, Tγ and Tμ cells were studied cytochemically in 30 patients with sarcoidosis and 28 healthy controls. The absolute numbers of T cells in patients with sarcoidosis significantly decreased, whereas thoso B cells remained within the normal range. Acid phosphatase and β-glucuronidase activities of both T and B cells were significantly elevated when compared to those of healthy controls. Negative correlations were observed between the two enzyme activities of T cells and T cell count. The percentage of Tγ cells significantly inceased, whereas that of Tμ cells remained within the normal range. Acid phosphatase and β-glucuronidase activities Tμ cells were significantly elevated whereas those of Tγ cells were at the same levels as in healthy controls. The two enzyme activities of Tμ cells in active cases tended to be higher than those in inactive cases. The elevation of acid phosphatase and β-glucuronidase activities of T cells seemed to be influenced by the elevation of these enzyme activities of Tμ cells. Tμ cells are considered to belong to helper cell. The marked enzyme activities of Tμ cells suggest the hyperfunction of helper cells. Moreover, the increased enzyme activities of B cells and elevated serum immunoglobulin levels which represent B cell hyperfunction may be evidence of the stimulated function of helper cells. Acid phosphatase and β-glucuronidase activities of T, B, Tγ and Tμ cells in patients with sarcoidosis seem to correlate with lymphocyte function in humoral and cellular immunity.
- 名古屋市立大学の論文
- 1980-11-04