SERUM ANGIOTENSIN-CONVERTING ENZYME AND SERUM LYSOZYME IN SARCOIDOSIS AND OTHER GRANULOMATOUS DISEASES
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概要
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Serum levels of angiotensin-converting enzyme (ACE) and lysozyme (LZM) were studied in sarcoidosis, tuberculosis, extrinsic allergic alveolitis, chronic beryllium disease, silicosis, and various other pulmonary diseases. Serum ACE was assayed spectrophotometrically. Serum LZM was assayed by the lyso-plate technique. Both serum ACE and LZM were elevated and correlated well with the extent or activity of sarcoidosis. Therefore, both enzymes may be derived from sarcoid granulomas. Serum ACE was correlated with serum LZM in sarcoidosis. However, serum LZM alone was elevated in some active cases, most of which had been suffering for 2 years or more. Thus, it is suspected that serum ACE activity may decline down earlier than serum LZM activity. In sarcoidosis whose ACE reduced to the normal level at 1 or 2 years from the onset of the disease, the prognosis was concluded to be favorable. Both serum ACE and LZM were elevated in chronic beryllium disease and silicosis, in which serum ACE correlated with serum LZM, although serum LZM in silicosis was not as high as in sarcoidosis. Dissociation of the two enzyme activities was observed in tuberculosis. Both enzymes were normal in extrinsic allergic alveolitis. Serum ACE was not elevated in various other pulmonary diseases. Thus, it is speculated that these findings may reflect the different properties of granulomas in sarcoidosis and other granulomatous diseases.A simukataneous determination of both serum ACE and LZM in sarcoidosis may be valuable in distinguishing sarcoidosis from other diseases except for chronic beryllium disease and silicosis, and in discriminating between stable and progressive conditions of sarcoidosis.
- 名古屋市立大学の論文
- 1980-11-04