SOME PROPERTIES OF SPONTANEOUS ELECTRICAL ACTIVITIES IN VASCULAR SMOOTH MUSCLE OF RAT PORTAL VEIN
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概要
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1. The spontaneous activities of the smooth muscle of rat portal vein were investigated under the various experimental conditions mostly with microelectrodes. 2. The muscle cells exhibited spontaneous periodic burst discharges of spikes accompanied by contractions. Each burst discharge was sperimposed on slow depolarization, and gradual depolarization (pacemaker potential) between successive burst discharges was observed in most of the recordings. 3. Frequent spike discharges were induced by depolarization caused by ouabain or Na^+ deficiency (Li^+ substitution), whereas K^+-free solution had small effects. 4. The spontaneous activities were facilitated by deficiency of Ca^<2+> or Mg^<2+> and suppressed in high concentration of either ion. 5. Effects of temperature on the electrical activities were observed between 33 and 38℃. The frequency of burst discharge changed transiently during warming and cooling processes. 6. The results obtained indicate that the membrane-bound Ca^<2+> and/or Mg^<2+> may play an important role to control the spontaneous activities by changing threshold level of the slow depolarization.
- 名古屋市立大学の論文
- 1980-11-04