SCANNING ELECTRON MIROSCOPIC OBSERVATIONS ON THE AORTIC ENDOTHELIUM IN HYPOVITAMIN C GUINEA PIGS WITH OR WITHOUT CHOLESTEROL ADMINISTRATION
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概要
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Morphologic changes of the endothelial cells in the descending aorta were studied by scanning electron microscopy in guinea pigs put on a hypovitamin C diet with or without cholesterol for 4 weeks. Flattening and desquamation of the endothelial cells were observed to be the initial change attributable to hypovitamin C. Swollen and disarranged endothelial cells, disruption of the cell junction and protrusion of the endothelial layer indicating thickening intima were observed in the chronic hypovitamin C animals. In the early phase of cholesterol feeding, the endothelial cells were flattened and craters were formed on their surfaces. The endothelial cell junction was indistinguishable and the cells tended to fuse with each other. Lesions showed greater advance with hypovitamin C and cholesterol-added diet as opposed to cholesterol-added diet alone. Desquamation of the endothelial cells and exposure of underlying intimal connective tissue, thrombocyte adhesion and deposition of fibrin were common findings in the late phase of cholesterol feeding with or without hypovitamin C. Crater formation was a characteristic feature of the endothelial changes due to cholesterol feeding. It may be concluded that hypovitamin C is an appropriate model for the induction of artherogenesis through endothelial injury.
- 名古屋市立大学の論文
- 1981-01-04