STUDIES ON CHANGES OF LIPID PEROXIDES AND VITAMIN E DURING PREGNANCY
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概要
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The aim of this study was to investigate the relationship between lipid peroxides and vitamin E in normal pregnancy and in toxemia of pregnancy. Lipid peroxide and vitamin E levels in the maternal of umbilical cord serum or placental tissues were determined by the methods of Yagi (for serum lipid peroxides), Abe and Katsui (for serum vitamin E), Masugi and Nakamura (for tissue lipid peroxides) and Abe et al. (for tissue vitamin E). Result obtained in this study were as follows: 1. In pregnant women with toxemia of pregnancy, higher serum vitamin E levels (1.40±0.62 mg/100 ml) were observed than in normal pregnant women (1.28±0.42 mg/100 ml), but in the serum lipid peroxide levels no significant difference was observed. 2. There was no correlation between maternal and umbilical cord serum lipid peroxide levels, but in most cases lower values in umbilical cord sera were observed. 3. A good correlation, (r) of 0.78, existed between the vitamin E levels in the serum of the mother and umbilical cord, however the mean vitamin E levels (0.27±0.10 mg/100 ml) observed in umbilical cord sera were significantly lower than those of maternal sera (1.28±0.42 mg/100 ml). 4. There was no significant difference in either lipid peroxide levels or vitamin E levels in the placental tissue obtained from normal deliveries and from deliveries with toxemia of pregnancy. Conclusively, it has been suggested that in pregnancy the increasing vitamin E levels might suppress the increase of lipid peroxides which in turn might cause toxemia of pregnancy.
- 名古屋市立大学の論文
- 1981-01-04