THE ROLE OF THE MAJOR HISTOCOMPATIBILITY COMPLEX IN PREGNANCY

概要

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HLA phenotype of A, B, C and DR loci of the parentsm cord blood, newborns and placenta in single or twin pregnancies was studied to elucidate the role of the major histocompatibility antigen in pregnancy. The specificity of HLA antigens between the newborn and cord blood did not always coincide, and the placenta possessed one father's haplotype and two mother's haplotypes. In observing the relationship between the number of feto-maternal incompatible antigens and Apgar score, icterus, placental weight, feto-placental weight ratio and sex ratio at birth, there was no significant difference except in sex ratio at birth. In the haplotype analytical study of single and twin pregnancies, A9-B22 haplotype frequency was high only in mothers who delivered twins. The HLA positive antibody ratio in the amniotic fluid was lower than in the retroplacental blood. The ratio at the multiparae showed twice as much as in primiparae in the retroplacental blood, but in amniotic fluid samples no significance was noticed. Serum reaction of DR locus showed a different pattern in the specimen obtained from each parturient or serum of cord blood and newborn. From the viewpoint of the matching of the father and mother or fetus and the major mismatched group. Thus, it was suggested that the HLA system definitely played an important role in pregnancy and that is served to difine some immunological aspects in pregnancy.
名古屋市立大学の論文
1981-01-04