EXPERIMENTAL STUDIES ON THE CAUSE OF RETINOPAHY OF PREMATURITY AND THE PREVENTIVE EFFECT OF α-TOCOPHEROL

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Studies were made to verify the finding that retinopathy of prematurity develops owing to cell membrane damage caused by an increase of lipid peroxide in experiments with 28 kittens and 5 cats. Oxygen is high concentration (70±1%) was administered to 13 kittens for 48 hours from day 3 after birth. Fifteen kittens and 5 cats were used as controls. The lipid peroxide and α-tocopherol levels in the blood and retina were measured by a fluorometric assay. The lipid peroxide levels in the blood and retina of kittens were higher than in the cats (p<0.005). The α-tocopherol level in the kitten blood plasma was lower than in the cats (p<0.001). The mean value of α-tocopherol in the cat retina was 9.34±2.79 μg/g, but very little was found in the kitten retina. The all 28 kittens showed a vitami E deficiency. Retinopathy of prematurity was observed in all of the 13 kittens administered oxygen. Then, the effect of α-tocopherol on retinopathy of prematurity was experimentally studied by using 21 kittens. Twelve kittens received subcutaneously 25 mg of tocopherol acetate daily from day 1 to day 20 after birth. Oxygen in a high concentration (70±1%) was given for 48 hours from day 3 after birth. In the treated kittens, the α-tocopherol levels in the blood plasma and the retina were about twenty to thirty times higher than those in the controls (p<0.001). The retinopathy of prematurity was recognized only in two of 12 treated kittens.
名古屋市立大学の論文
1981-01-04

EXPERIMENTAL STUDIES ON THE CAUSE OF RETINOPAHY OF PREMATURITY AND THE PREVENTIVE EFFECT OF α-TOCOPHEROL

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