EFFECTS OF SEX STEROID HORMONES AND PROSTAGLANDINS ON THE SYNTHESIS OF GLYCOSAMINOGLYCANS IN CULTURED CELLS FROM THE HUMAN UTERINE CERVIX

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概要

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• In order to clarify the mechanism of hormonal regulation on the ripening of the uterine cervix during late pregnancy and labor, the effects of sex steroid hormones and prostaglandins (PGs) on the synthesis of glycosaminoglycans (GAG) were studied in the cultured cells derived from the human uterine cervix. Estradiol-17β(E_2) induced a marked increase in radioactivity of ^<14>C-glucosamine-incorporated substance, which was ascertained to be mainly hyaluronic acid (HA) as identified by Dowex 1-X2 column chromatography and electrophoresis on cellulose acetate membrane. On the other hand, this action of E_2 was inhibited by progesterone. All of PGE_1, PGE_2 and PGF_<2α> were also proved to have a stimulant effect on the synthesis of GAG, particularly HA. These results suggest that sex steroid hormones and PGs may contribute to cervical ripening during late pregnancy and labor with increasing the synthesis of GAG in the cervical connective tissue.

• 1981-12-28

著者

• 田中 正司

  Department Of Obstetrics And Gynecology Nagoya City University Medical School

関連論文

• EFFECTS OF SEX STEROID HORMONES AND PROSTAGLANDINS ON THE SYNTHESIS OF GLYCOSAMINOGLYCANS IN CULTURED CELLS FROM THE HUMAN UTERINE CERVIX

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