CALCIUM-INDUCED TENSION OF MESENTERIC ARTERIES FROM SPONTANEOUSLY HYPERTENSIVE RATS
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概要
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The contractile response of arteries to Ca^<2+> was studied using helical strips of mesenteric artery from six-week-old male spontaneously hypertensive rats (SHR) and the age- and sex-matched normotensive Wistar-Kyoto rats (WKY). Blood pressure was 130±5 mmHg for SHR and 110±5 mmHg for WKY (M±SD). 1. At high Ca^<2+> concentrations (3×10^<-4> M to 3×10^<-3> M), the Ca^<2+>-induced tension of mesenteric arterial strips per cross sectional area was significantly greater in SHR than in WKY in the presence of noradrenaline (NA, 10^<-5> M) or high K^+ (121mM)(p<0.001). At low Ca^<2+> concentrations (10^<-5> M with NA and 3×10^<-5> M with high K^+), the tension was smaller in SHR strips than in WKY (p<0.05). 2. Tension development at each Ca^<2+> concentration expressed as percent of the maximum tension of each strip, was significantly smaller in SHR strips than in WKY in the presence of NA or in high K^+ solution. 3. Diltiazem (Ca-antagonist) shifted the dose-response curve of Ca^<2+>-induced tension to the right equally in SHR and WKY strips. The drug inhibited the maximum Ca^<2+>-induced tension in both SHR and WKY. The inhibition of the maximum tension by the drug was greater in SHR strips than in WKY in the presence of NA, but there was no difference in high K^+ solution. It is suggested that the contractile abnormality to Ca^<2+> in the young SHR small arteries may be a possible cause of hypertension in SHR.
- 名古屋市立大学の論文
- 1981-12-28