COMPARATIVE STUDIES ON THE BILE ACID METABOLISM OF NORMAL AND ALCOHOL-DAMAGED RAT LIVERS USING ISOLATED LIVER PERFUSION
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概要
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The metabolism of ursodeoxycholic acid (UDC) in the liver was investigated using isolated rat liver perfusion. Bile acids were analyzed by high performance liquid chromatography (HPLC). When unconjugated UDC was administered to the perfusion medium 30 min after initiating perfusion, the bile acids which increased in the bile included not only unconjugated UDC, glycine-conjugated UDC, taurine-conjugated UDC but also taurine-conjugated chenodeoxycholic acid and two peaks that could not be identified, namely, P_1 and P_x. However, it was strongly suggested that P_1 was taurine-conjugated β-muricholic acid and P_x was a metabolite of UDC. On the other hand, in the bile of chronic alcoholic rats a marked reduction in deoxycholic acid, a marked increase in chenodeoxycholic acid and a marked increase in unconjugated cholic acid were observed. In the UDC adding experiment using isolated rat liver perfusion, a reduction in the bile secretion of the bile acid-independent fraction was proved in the alcoholic group. In addition, among the various patterns of bile acids which increased in the bile after addition of UDC, glycine-conjugated UDC exhibited a significant increase in the alcoholic group.
- 名古屋市立大学の論文
- 1982-07-30