THE SIGNIFICANCE OF PREGNANCY ASSOCIATED SUBSTANCES IN HUMAN PREGNANT SERA AS INDICATORS PLACENTAL FUNCTION

概要

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The concentrations of heat-stable alkaline phosphatase (HSAP), cystine aminopeptidase (CAP), human chorionic somatomammotropin (hCS), pregnancy-specific β-1-glysoprotein (SP-1), and pregnancy-associate α-2-glycoprotein (SP-3) in sera obtained from 96 normal pregnant women and 62 pregnant women with toxemia, diabetes, SFD or other complications were determined simultaneously during pregnancy. The correlations were investigated between placenta or birth weight or newborn infant and these above substances in pregnant sera obtained within 7 days before delivery. In normal pregnancy HSAP, CAP, hCS, and SP-1 concentrations increased with the course of gastation. Except for SP-3, all of these substances had a slight correlation either to the placenta or birth weight of newborn infant. In twin pregnancy all these substances except SP-3 evidenced higher levels than in normal pregnancy. In severe toxemia of pregnancy the concentrations of CAP, hCS and SP-1 were lower than in normal pregnancy. Significantly lower levels of hCS and SP-1 were noted in pregnant women carring small for date fetuses from the 30th week of gestation to term. These results suggested that serum concentrations of HSAP, CAP, hCS and SP-1 could be clinicaly usuful in monitoring high risk pregnancy.
名古屋市立大学の論文
1982-11-12