STUDIES ON COMPLEMENT ACTIVATION IN ABORTION AND TOXEMIA OF PREGNANCY
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概要
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Serum levels of complement components of alternative pathway and classical pathway were studied in normal and abnormal pregnancies. The subjects included 103 cases of normal pregnancy, 34 patients with threatened abortion and 33 patients with toxemia of pregnancy. The results were as follows: (1) In normal pregnancy the levels of serum CH50 and complement components (except C1q and properdin) were slightly or significantly increased. (2) Patients with threatened abortion who eventually aborted showed significant decreases in the levels of CH50, factor B, C3, C5 and C9, compared to those women with normal pregnancies of the same gestational age. (3) When compared to women with normal pregnancies of the same gestational age, patients with mild toxemia of pregnancy showed significant decreases in the levels of serum C1q and C4, while patients with severe, toxemia of pregnancy showed significant decreases in the levels of serum CH50, properdin, β1H globulin, C1q, C4 and C3. These findings clearly demonstrated that the complement system in patients with threatened abortion who ultimately aborted was activated mainly via the alternative pathway, while in patients with severe toxemia of pregnancy it was activated via both classical and alternative pathways. This study showed that though immune reactions are involved in both abortion and toxemia, they differed in the pathway pattern of complement activation, and suggested the possibility of a different immunological pathogenesis in the two conditions.
- 1982-12-25