THE EFFECT OF BILATERAL CAROTID ARTERY LIGATION AND HYPOTENSION INDUCED BY BLEEDING UPON THE ENERGY METABOLISM OF THE RAT BRAIN: CRITICAL CEREBRAL BLOOD FLOW

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In order to study the effect of ischemia on the rat cerebral energy metabolism, biochemical and physiological changes induced by bilateral carotid ligation and hypotension was examined. The local cerebral blood flow of the parietal cortex was measured using the hydrogen clearance method. Ligation of the carotid arteries at normal blood pressure decreased blood flow in the parietal regions by about 53% in both hemispheres. Further decrease of cerebral blood flow was achieved by the reduction of mean arterial blood pressure by exsanguination. Above the mean arterial blood pressure of 80 mmHg, nosignificant changes in the cerebral energy metabolism as represented with the activities of ATP, creatinephosphate, and lactate were observed. When the mean arterial blood pressure was 80 mmHg, local cerebral blood flow was about 20 ml/100g/min. At 70 mmHg in blood pressure, local blood flow was about 12 ml/100g/min and the cerebral metabolism decreased significantly. At this blood pressure electroencephalographic changes associated with ischemia were also evaluated: Remarkable changes characterized by apparent slow waves or low amplitude waves occured invariably. It may be concluded that the lower limit of cerebral blood flow in order to maintain a normal cerebral energy metabolism in the rat is between 12 and 20 ml/100g/min.
名古屋市立大学の論文
1983-12-23