ラット肝臓の形質膜およびミトコンドリア膜のリン脂質に及ぼすクロフィブレートの影響

概要

論文の詳細を見る
To elucidate effects of clofibrate, a hypolipidemic drug, on phospholipids of plasma and mitochondrial membranes from rat liver, the diet containing clofibrate 0.5%(w/w)was fed for 15 days. Clofibrate administration resulted in enlargement of the liver accompanying with proliferation of peroxisomes. Clofibrate increased phospholipids content of per g of liver by 125% in comparison with the control. Although the clofibrate treatment showed a significant decrease of cardiolipin of mitochondrial inner membranes, no alterations in other membranous phospholipids were observed. Clofibrate also brought into alterations on fatty acid composition of isolated glyceroophosopholipids from plasma and mitochondrial membranes. The characteristic alteration except posphatidyletanolamine was a decrease of 20:4n-6 accompanied by an increase of 16:0. Clofibreate also decreased very long chain fatty acids of sphingomyelin in plasma membranes. These results suggest clofibrate affects both phospholipids and fatty acids metabolism in rat liver.