経腸栄養食の代謝と生体に及ぼす影響について
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概要
- 論文の詳細を見る
The present study was undertaken to reveal the availability, metabolism and method of enteral hyperalimentation employing the low residue diet (SF) or the elemental diet (ED). In the experiment on the Wistar strain rats, the increase of body weight and the water-soluble protein of muscle and its Ml fraction, as indices of nutritional status, revealed the well maintained nutrition in either SF or ED, suggesting the availability of both diets. The cumulative expired CO_2 showed somewhat slow utilization of ED as compared with the SF. Despite low fat content in its constituents in ED, the hepatic triglycerides (TG) increased remarkably in the ED group while the hepatic glycogen was relatively scanty. Addition of lipides to ED showed the same contents in TG and glycogen to those in the control. In oral administration of 200 Cal/200ml in SF to patients, the changes of gastrin and blood sugar were greater in 15 minutes group than in 60 minutes group, whereas the absorption was lower in 15 minutes group than in 60 minutes group. On the other hand, in ED each index showed the prompt and balanced changes even in 15 minutes administration as compared with the SF group. In both SF or ED administration, however, every laboratory finding showed the almost within normal limits without any severe or lethal complications. Thus, the nutritional conditions of debilitated patients were possibly improved sufficiently when these diets were given more than 1,800 Cal/day as the enteral hyperalimentation. Of the indications, ED was supposed to be most effective in the cases to avoid intestinal stimulation, while SF was preferable to ED in the cases of obstruction or stenosis of upper alimentary tract.
- 神戸大学の論文