ALTERATIONS OF T LYMPHOCYTE SUBSETS IN PATIENTS WITH TOXEMIA OF PREGNANCY

概要

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Peripheral blood lymphocyte subsets in normal pregnancy and toxemia of pregnancy have been studied by using double marker cell method and the monoclonal antibodies OKT3 (peripheral Tcells), OKT4 (helper/inducer T cells) and OKT8 (suppressor/cytotoxic T cells). No significant differences were found in the percentage of T cells, B cells, double marker cells and null cells as determined by double marker cell method in the following groups: normal pregnancy (21 cases), mild toxemia of pregnancy (15 cases), and severe toxemia of pregnancy (11 cases). On the other hand, mild type (16 cases) showed a significant decrease (p<0.001) in the proportion of OKT4-positive T cells (T4^+) and a significant increase (p<0.001) in the proportion of OKT8-positive T cells (T8^+), but severe type (13 cases) displayed no statistical differences in T4^+ and T8^+, as compared with normal pregnancy (26 cases). In addition, the response of maternal mononuclear cells to various mitogens (phytohemagglutinine concanavalin A, pokeweed mitogen) was determined in these groups. The mononuclear cells of patients with mild and severe toxemia of pregnancy showed a significantly reduced response to these mitogens as compared with the normal pregnant controls. These results suggest that celluar immunity may participate in the pathogenesis of toxemia of pregnancy.
名古屋市立大学の論文
1984-12-25