EXPERIMENTAL STUDIES ON ANTIOXIDATIVE EFFECT OF COENZYME Q_<10> ON THE RETINA
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概要
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The lipid peroxide level in the chick retina was examined under various conditions in vitro and in vivo to verify the antioxidative effect of coenzyme Q_<10> (CoQ_<10>). The levels of CoQ_<10> in the retina, liver, and heart were 8.4 μg/g, 82.3 μg/g and 74.9 μg/g wet weight, respectively. In the suspension of retina only, CoQ_<10>exhibited no antioxidative effects, but in the retina mixed with chick heart mitochondria CoQ_<10> showed marked inhibition of lipid peroidation as strong as that by dl-α-tocopherol. Accordingly, it was confirmed that CoQ_<10> can act as an antioxidant in much mitochondria and that the antioxidative effect of CoQ_<10> displays organ specificity. Sixty kittens were administered a high concentration (70±1%) of oxygen for 48 h from day 3 after birth. In 11 kittens subcutaneously administered 10 mg of CoQ_<10> (group A), retinopathy of prematurity (ROP) was detected in 18 of 22 eyes. In 7 kittens receiving an equal volume of a vehicle placebo (group B), ROP was detected in 13 of 14 eyes. There was no significant difference between group A and B. In 23 kittens given 5 mg of CoQ_<10> and 12.5 mg of tocopherol acetate (group C), ROP was seen only in 11 of 46 eyes. In 19 kittens administered an equal volume of a vehicle placebo and 12.5 mg of tocopherol acetate (group D), ROP was seen in 31 of 38 eyes. The retina in which ROP developed showed a higher level of lipid peroxide than that in the normal retina.
- 名古屋市立大学の論文
- 1984-12-25