Reaction of Aromatic N-Oxides with Dipolarophiles : V. 1,3-Cycloaddition of 2-Substituted Pyridine N-Oxides with Phenyl Isocyanates

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概要

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• The reaction of 2,3-lutidine N-oxide (I) with phenyl isocyanate (IIa) in dimethylformamide at 110℃ gave a 1:2 adduct (IIIa). Under reflux in ethanolic potassium hydroxide, IIIa readily lost a component of IIa and was converted to 5-methyl-6-N-phenylcarbamoylmethyl-3-pyridinol (IVa) in 95% yield. 2-Phenylpyricline N-oxides (V-VII) reacted with phenyl isocyanates (II) to afford 1:1 cycloadducts (IX-XI and XII-XIV). The reaction of 2-(p-nitrophenyl)pyridine N-oxide (VIII) with hIa directly afforded 2-anilino-6-(p-nitrophenyl)pyridine derivatives (XIVa and XVa).

• 福山大学の論文

著者

• HISANO TAKUZO

  Faculty of Pharmaceutical Sciences, Kumamoto University

• Hisano Takuzo

  Faculty Of Pharmaceutical Sciences Kumamoto University

• MATSUOKA TOSHIKAZU

  Faculty of Pharmaceutical Sciences, Kumamoto University

• FUKUNAGA KAZUHIRO

  Faculty of Pharmaceutical Sciences, Kumamoto University

• ICHIKAWA MASATAKA

  Faculty of Pharmaceutical Sciences, Kumamoto University

• Ichikawa Masataka

  Faculty Of Pharmaceutical Sciences Kumamoto University

• Fukunaga Kazuhiro

  Faculty Of Pharmaceutical Sciences Kumamoto University

• Matsuoka Toshikazu

  Faculty Of Pharmaceutical Sciences Kumamoto University

関連論文

• Synthesis of Benzoxazoles, Benzothiazoles and Benzimidazoles and Evaluation of Their Antifungal, Insecticidal and Herbicidal Activities
• Reaction of Aromatic N-Oxides with Dipolarophiles : V. 1,3-Cycloaddition of 2-Substituted Pyridine N-Oxides with Phenyl Isocyanates

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