無症候性微少血尿症の病態解析 : 特に凝固溶能の立場より

概要

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As a result of the spread of urinalysis in recent years with regard to the mass physical examination at school, cases of asymptomatic microhematuria were often discovered from the occult blood reaction test of urine, in spite of the fact that their proteinuria was slight or negatine. To clarify the pathogenesis of asymptomatic microhematuria, both the clinical picture and the ecological mechanism of it were examined and the results were obtained as follows. 1.Incases of asymptomatic hemtlturia, bacterinuria was detected from 37.7% of them and abnormal findings on IVP were obtained from 46.5% of them. 2.Cases of microhematuria indicated urinary FDP in a high percentage of 70.5%, and for the most part, microhematuria was considered to be due to the localized disturbance of coagulation and fibrinolysis from parenchymal impairment of the kidney. 3.The urinary level of α_1-antitrypsin, α_2-macroglobulin, prothromlin and/or antithrombin III differed according to the presence or absence of hematuria, and thus the presence of them in urine is suggestive of the rational organic defence mechanism against the abnormal coagulation and fibrinolysis in the kidney.
神戸大学の論文